Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells
نویسندگان
چکیده
منابع مشابه
Regulatory T Cells and Myeloid-Derived Suppressor Cells in Patients with Peptic Ulcer and Gastric Cancer
Background: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. Objective: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease...
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Myeloid-derived suppressor cells are a heterogeneous group of pathologically activated immature cells that play a major role in the negative regulation of the immune response in cancer, autoimmunity, many chronic infections, and inflammatory conditions, as well as in the regulation of tumor angiogenesis, tumor cell invasion, and metastases. Accumulation of myeloid-derived suppressor cells is go...
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† H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612 Departments of Internal and Molecular Medicine, University of South Florida, Tampa, FL, 33612 Address for correspondence: Srinivas Nagaraj: [email protected]; Ph:813-974-4585, FAX: 813-905-9913 or Dmitry Gabrilovich, H. Lee Moffitt Cancer Center 12902 Magnolia Dr., Tampa, FL, 33612; [email protected]; Ph:...
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Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to suppress T-cell responses. Recently, we demonstrated that the human-pathogenic fungi Candida albicans and Aspergillus fumigatus induced a distinct subset of neutrophilic MDSCs. To dissect Candida-mediated MDSC induction in more depth, we studied the relative efficacy of different pathogenic non-al...
متن کاملregulatory t cells and myeloid-derived suppressor cells in patients with peptic ulcer and gastric cancer
background: regulatory t cells (tregs) and myeloid-derived suppressor cells (mdscs) are two main regulatory cells modulating the immune responses in inflammation and cancer. objective: to investigate and compare tregs and mdscs in peptic ulcer and gastric cancer. methods: patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (nud, n=22), peptic ulcer disease...
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ژورنال
عنوان ژورنال: Seminars in Cancer Biology
سال: 2012
ISSN: 1044-579X
DOI: 10.1016/j.semcancer.2012.01.010